Lung Diseases

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Mitochondrial dysfunction is rapidly developing as a key pathological feature of early and persistent lung disease. In particular, mitochondria are emerging as central to the pathological processes and clinical phenotypes associated with a range of lung diseases.

Abnormal mitochondrial signaling plays an important role in many lung diseases:

• Altered mitochondrial biogenesis and mitogenesis
• Increased mtDNA mutations
• Abnormal mitochondrial-derived signaling
• Activation of mtDAMPs

Figure 1. Relationship between mitochondria dysfunction and lung diseases (Fang et al., 2019).

Comprehending the molecular mechanisms that modulate mitochondrial processes in lung cells will allow for a better definition of the phenotypes and clinical manifestations associated with respiratory diseases and explore potential diagnostic and therapeutic targets.

Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated lung diseases and possible interventions, with professional services and products to support your research.

Specific Lung Diseases

Creative Biogene offers comprehensive testing services for the evaluation of a variety of lung diseases.

You could benefit from our established models of a variety of lung diseases. We offer comprehensive mitochondria-focused testings and services with the advantage of our cell-based and animal-based models.

Customized options exist if the diseases you focus on are not on the list. We have the capability of customizing our assays and models. Please do not hesitate to contact us if you require customized services.

Our Capabilities

In vivo/in vitro assessment of mitochondrial function can be a useful tool for mechanistic studies of lung diseases, as well as for the evaluation of (novel) therapeutic interventions.

Creative Biogene provides rapid mitochondrial function testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.

Quotation and Ordering

If you have any special needs or questions regarding our services, please feel free to contact us. Creative Biogene looks forward to cooperating with you in the future.

Reference

1. Fang, T., Wang, M., Xiao, H., & Wei, X. (2019). Mitochondrial dysfunction and chronic lung disease. Cell Biology and Toxicology, 35(6), 493-502.

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