Mitochondrial Fatty Acid Metabolism
Creative Biogene uses GC/MS combined with various fatty acid isotope standards to detect and analyze more than 40 fatty acids. Our solution significantly improves the stability and the accuracy of qualitative and quantitative analysis.
Fatty acids are a kind of carboxylic acids formed by the connection of hydrocarbon groups composed of hydrocarbon atoms and carboxylic acids. Fatty acids are divided into three categories. One is saturated fatty acids, and their hydrocarbon groups are alkyl groups composed of single bonds. The second category is monounsaturated fatty acids, within which the hydrocarbon group contains an olefin group with a carbon-carbon double bond. Polyunsaturated fatty acids are in the last category, with hydrocarbon groups contain olefin groups with multiple carbon-carbon double bonds.
Figure 1. Several different fatty acids. (from Wikipedia)
The groups on both sides of the double bond of natural fat tend to be cis fatty acids, so most of the fatty acids in natural oils in unprocessed foods are cis fatty acids. On the other hand, the content of natural trans fatty acids is relatively small, mainly in the fat and milk of ruminants such as cattle and sheep. Triglyceride, which is formed by glycerol and trimolecular long-chain fatty acids, is the main component of fat.
General Strategy
Our detection platform includes GC/MS and ELSD or DAD detectors to separate and identify samples. Changes in fat content can be accurately and efficiently detected. At present, more than 40 kinds of fats can be detected, such as unsaturated fatty acids and acylcarnitine.
Creative Biogene detection platform for similar substances of common fat or above fat can be combined with standard samples for detection. For rare fat molecules, customized testing can be provided if a standard sample, Creative Biogene testing platform is provided. Besides, the Creative Biogene testing platform also provides a biochemical method, high-performance liquid chromatography, LC-MS fat determination services to meet your different needs.
Creative Biogene always provides you with customized services for mitochondrial research, and our one-stop research and analysis platform can meet all your research needs.
Our Advantages
- Rich experience in the detection of mitochondrial fatty acid metabolism
- Outstanding research team
- Unique integrated service for mitochondrial research
- Reliable data and results
- Rapid turnaround and cost-effective
Creative Biogene has the most professional team to serve customers around the world. If you have any questions about the content of this service, please feel free to contact us. We look forward to your contact.
References
- Sander M. H., et al. " The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders. " Annual Review of Physiology, 2016, 78(1): 23-44.
- Graham P. H., et al. " Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals. " The American Journal of Clinical Nutrition, 2009, 89(1): 455S-462S.
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