Plasma Amino Acid Profile
Creative Biogene provides a comprehensive range of Biofluid Biochemistry testing services to assist researchers in mitochondria-related disease studies.
The blood levels of different amino acids vary significantly in mitochondrial dysfunctional organisms, especially alanine and branched-chain amino acids (BCAAs).
- Amino acid analysis can reveal elevated alanine, as a product of the transamination of pyruvate by alanine aminotransferase.
- Elevated levels of the branched-chain amino acids could be an indication for an E3 deficiency; an enzyme module shared by the branched-chain amino acid dehydrogenase, 2-oxoglutarate dehydrogenase, and pyruvate dehydrogenase.
- Generalized aminoaciduria is sometimes seen as a result of renal tubulopathy caused by mitochondrial defects.
Figure 1. Biochemical pathways and metabolism of amino acids in mitochondria.
A plasma amino acid profile may show an elevation of alanine level in plasma which reflects lactic acidemia and branched-chain amino acids which are catabolized in mitochondria.
Creative Biogene provides accurate plasma amino acid testing services to precisely evaluate the metabolism changes induced by mitochondria dysfunction.
Technical Characteristics
- We provide accurate plasma amino acid determining methods through fully automated biochemical analysis and LC/MS.
- Easy-to-use assay kits are also available.
- Only a small quantity of samples is required.
- Creative Biogene will provide a full report of the experimental procedure, experimental data and analysis results.
Creative Biogene works with you to validate and explore the pathogenesis of mitochondria-associated diseases and possible interventions, with professional Biofluid Biochemistry assay services to support your research.
Related Services
Creative Biogene provides rapid Biofluid Biochemistry testing services, allowing clients to accurately analyze the relationship between disease and mitochondria.
Our Advantages
- Rich experience in mitochondrial biochemical assay analysis
- Outstanding research team
- Unique integrated service for mitochondrial research
- Reliable data and results
- Rapid turnaround and cost-effective
Quotation and Ordering
Creative Biogene has the most professional team to serve customers around the world. If you have any questions about the content of this service, please feel free to contact us. We look forward to your contact.
Reference
- Hewton, Keeley G., Amritpal S. Johal, and Seth J. Parker. "Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism." Metabolites 11.2 (2021): 112.
For Research Use Only. Not For Clinical Use Or Individual Users.
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