Mitochondrial Toxicity Detection

Creative Biogene has established a complete and mature mitochondrial toxicity testing platform, which provides a complete solution for all stages of in vitro mitochondrial safety analysis and the determination of key parameters of mitochondrial function.

A large proportion of drugs are withdrawn from the market every year because of the side effects that have not been found in the preclinical or mid-term. Usually, these side effects are cardiotoxicity and hepatotoxicity caused by mitochondrial dysfunction. Therefore, the determination of mitochondrial toxicity is very important in drug development, and the evaluation of mitochondrial toxicity in the early stage of drug development can prevent the waste of resources in later clinical research, thus saving development time and cost.

Figure 1. Processes related to mitochondrial dysfunction.

Creative Biogene has established a complete and mature mitochondrial toxicity testing platform, which can provide a complete solution for in vitro mitochondrial safety analysis and determination of key parameters of mitochondrial function, and assist your drug development and evaluation.

Figure 2. Possible sites of mitochondrial function induced by heterologous organisms resulting in mitochondrial toxicity. (James H., et al. , 2006)

Creative Biogene always provides you with customized services for mitochondrial research, and our one-stop research and analysis platform can meet all your research needs.

General Strategy

Detection of mitochondrial toxicity by oxygen sensitive probe based on fluorescence

This method is suitable for the analysis of mitochondria from different tissues.

Our Advantages

Rich experience in mitochondrial toxicity detection
Outstanding research team
Unique integrated service for mitochondrial research
Reliable data and results
Rapid turnaround and cost-effective

Creative Biogene has the most professional team to serve customers around the world. If you have any questions about the content of this service, please feel free to contact us. We look forward to your contact.

Reference

James H., et al. “ Investigation of drug-Induced mitochondrial toxicity using fluorescence-based oxygen-sensitive probes. ” Toxicological Sciences, 2006, 92(1): 186-200.

For Research Use Only. Not For Clinical Use Or Individual Users.

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